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pentobarbital will lessen the level or outcome of parecoxib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unidentified.pentobarbital will decrease the extent or influence of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration. Solid or reasonable CYP3A